Automating microfluidic part verification

@article{Pawell2015AutomatingMP,
  title={Automating microfluidic part verification},
  author={Ryan S. Pawell and Robert A. Taylor and Kevin V. Morris and Tracie Jacqueline Barber},
  journal={Microfluidics and Nanofluidics},
  year={2015},
  volume={18},
  pages={657-665}
}
Abstract Microfluidic devices promise to significantly advance the field of medicine by providing diagnostic tools that may be administered at the point-of-care (POC). Currently, a major barrier to entry for POC microfluidic diagnostic technologies is part qualification where specific features of a microfluidic technology must be qualified during the manufacturing process to ensure the device performs properly, e.g., Tantra and van Heeren (Lab Chip 13:2199, 2013). Additionally, microfluidic… 
Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties
TLDR
This review covers the breadth of microfluidic platforms for isolation of cellular subtypes based on their intrinsic and extrinsic properties and concludes by highlighting the advantages and limitations of the reviewed techniques which then suggests future research directions.
Self-Adaptive Time-Series Based Forecast Models for Predicting Quality Criteria in Microfluidics Chip Production
TLDR
A dynamic update of the non-linear PLS-fuzzy models with new on-line data is achieved, embedding the option to smoothly outweigh older sample to increase flexibility and there is significant non- linearity in the predictive modeling problem.
Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis
TLDR
It could be demonstrated that downregulation of Oct4 by microRNAs-299-3p in breast cancer and fibrosarcoma cells lead to a decreased invasiveness in a microfluidic chip assay and causes apoptosis in cancer cells.
Virtual Quality control using bidirectional LSTM networks and gradient boosting
TLDR
A machine learning model based on bidirectional Long Short-term Memory recurrent neural networks and gradient boosting is applied to a set of real world data from microfluidic chip production plant and it is shown that despite limited amount of training data compared to the large input space, it is capable of predicting the relevant quality values, and especially their basic trends over time.

References

SHOWING 1-10 OF 29 REFERENCES
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays.
TLDR
A complete process is presented that describes the fabrication of polystyrene (PS) microfluidic devices with similar cost and time expenditures as PDMS-based devices with emphasis on creating methods that can compete with PDMS fabrication methods in terms of robustness, complexity, and time requirements.
Investigation of hot roller embossing for microfluidic devices
Microfluidics for most bio-related diagnostic applications typically requires single usage disposable chips to avoid bio-fouling and cross-contamination. Individual piece-wise manufacturing of
Manufacturing and wetting low-cost microfluidic cell separation devices.
TLDR
A simple, yet robust protocol for thermoplastic DLD devices using regulatory-approved materials and biocompatible methods is developed, allowing for volumetric flow rates of 660 μl min(-1) while reducing the manufacturing time to <1 h.
Micro-injection moulding of polymer microfluidic devices
Microfluidic devices have several applications in different fields, such as chemistry, medicine and biotechnology. Many research activities are currently investigating the manufacturing of integrated
Engineers are from PDMS-land, Biologists are from Polystyrenia.
TLDR
A critical evaluation of the strengths and limitations of PDMS and PS in relation to the advancement and future impact on microfluidic cell-based studies and applications is provided and guidelines for researchers who desire to choose the most suitable material for their application are provided.
Limits of parabolic flow theory in microfluidic particle separation : a computational study
Microfluidic particle separation technologies are useful for enriching rare cell populations for academic and clinical purposes. In order to separate particles based on size, deterministic lateral
Product qualification: a barrier to point-of-care microfluidic-based diagnostics?
TLDR
The issue surrounding product qualification as a potential barrier to market success in microfluidics-based diagnostics is considered and the need for a community-based effort that is necessary to speed up the product qualification process is underlined.
Automated Quality Inspection of Microfluidic Chips Using Morphologic Techniques
TLDR
Based on a comparison of measured topographies with design data, a coherent solution to four central tasks in the quality assessment of injection moulded polymer devices is provided: determination of channel depth, identification of burrs, calculation of transcription accuracy, and detection of defective regions.
A vector-free microfluidic platform for intracellular delivery
TLDR
A microfluidic approach to delivery in which cells are mechanically deformed as they pass through a constriction 30–80% smaller than the cell diameter results in the formation of transient holes that enable the diffusion of material from the surrounding buffer into the cytosol.
Hot Embossing: Theory and Technology of Microreplication
This book is an overview of replication technology for micro- and nanostructures, focusing on the techniques and technology of hot embossing, a scaleable and multi-purpose technology for the
...
...