Automatic modeling of mammalian olfactory receptors and docking of odorants.

  title={Automatic modeling of mammalian olfactory receptors and docking of odorants.},
  author={Guillaume Launay and St{\'e}phane T{\'e}letch{\'e}a and Fallou Wade and E. Pajot-Augy and Jean-François Gibrat and Guenha{\"e}l Sanz},
  journal={Protein engineering, design & selection : PEDS},
  volume={25 8},
We present a procedure that (i) automates the homology modeling of mammalian olfactory receptors (ORs) based on the six three-dimensional (3D) structures of G protein-coupled receptors (GPCRs) available so far and (ii) performs the docking of odorants on these models, using the concept of colony energy to score the complexes. ORs exhibit low-sequence similarities with other GPCR and current alignment methods often fail to provide a reliable alignment. Here, we use a fold recognition technique… CONTINUE READING

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