Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study.

@article{Hettne2007AutomaticMO,
  title={Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study.},
  author={Kristina M. Hettne and Marc Weeber and Marja L Laine and Hugo Ten Cate and Scott Boyer and Jan A. Kors and Bruno G. Loos},
  journal={Journal of clinical periodontology},
  year={2007},
  volume={34 12},
  pages={
          1016-24
        }
}
AIM The aim of the current report was to generate and explore new hypotheses into how, in a pathophysiological sense, atherosclerosis and periodontitis could be linked. MATERIAL AND METHODS Two different biomedical informatics techniques were used: an association-based technique that generated a ranked list of genes associated with the diseases, and a natural language processing tool that extracted the relationships between the retrieved genes and lipopolysaccharide (LPS). RESULTS This… CONTINUE READING

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