Automatic identification of subcellular phenotypes on human cell arrays.

@article{Conrad2004AutomaticIO,
  title={Automatic identification of subcellular phenotypes on human cell arrays.},
  author={Christian Conrad and Holger Erfle and Patrick Warnat and Nathalie Daigle and Thomas L{\"o}rch and Jan Ellenberg and Rainer Pepperkok and Roland Eils},
  journal={Genome research},
  year={2004},
  volume={14 6},
  pages={1130-6}
}
Light microscopic analysis of cell morphology provides a high-content readout of cell function and protein localization. Cell arrays and microwell transfection assays on cultured cells have made cell phenotype analysis accessible to high-throughput experiments. Both the localization of each protein in the proteome and the effect of RNAi knock-down of individual genes on cell morphology can be assayed by manual inspection of microscopic images. However, the use of morphological readouts for… CONTINUE READING
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