Automatic Detection of Spironolactone - Related Adverse Drug Events

  title={Automatic Detection of Spironolactone - Related Adverse Drug Events},
  author={Christine Huang and Laura A. Noirot and Richard M. Reichley and Dennis A. Bouselli and W. Claiborne Dunagan and Thomas C. Bailey},
  journal={AMIA ... Annual Symposium proceedings. AMIA Symposium},
Due to increasing reports of spironolactone associated life-threatening hyperkalemia, we implemented a rule in our automated event detection system to monitor serum potassium results in patients receiving spironolactone. In 2004, 419 (10.49%) of 3995 admissions at 3 BJC HealthCare hospitals were identified as having hyperkalemia while on spironolactone. For a 9-month period in one facility, 33 of 52 automatically detected potential ADEs had been validated by pharmacists through manual chart… CONTINUE READING

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