Automatic 3D neuron tracing using all-path pruning

  title={Automatic 3D neuron tracing using all-path pruning},
  author={Hanchuan Peng and Fuhui Long and Eugene W. Myers},
  booktitle={Bioinformatics [ISMB/ECCB]},
MOTIVATION Digital reconstruction, or tracing, of 3D neuron structures is critical toward reverse engineering the wiring and functions of a brain. However, despite a number of existing studies, this task is still challenging, especially when a 3D microscopic image has low signal-to-noise ratio (SNR) and fragmented neuron segments. Published work can handle these hard situations only by introducing global prior information, such as where a neurite segment starts and terminates. However, manual… CONTINUE READING
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