Automated whole-genome multiple alignment of rat, mouse, and human.

  title={Automated whole-genome multiple alignment of rat, mouse, and human.},
  author={Michael Brudno and Alexander Poliakov and Asaf A. Salamov and Gregory M. Cooper and Arend Sidow and Edward M. Rubin and Victor Solovyev and Serafim Batzoglou and Inna Dubchak},
  journal={Genome research},
  volume={14 4},
We have built a whole-genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline that combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment and consists of two main steps: (1) alignment of the mouse and rat genomes, and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting… CONTINUE READING