Automated systems to assess weights and activity in group housed mice

@inproceedings{Noorshams2017AutomatedST,
  title={Automated systems to assess weights and activity in group housed mice},
  author={Omid Noorshams},
  year={2017}
}
In order to investigate central nervous system disorders such as Parkinson’s disease and Alzheimer disease, genetically altered mice are used. These mouse models should be frequently monitored to assess disease progression. Most monitoring system for activity and weighing require remove of the animals from their homecage and place them in a novel environment. During these procedures animals may undergo the stress which can alter the behavioral and social phenotypes. We developed two systems to… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System
TLDR
It is demonstrated that the system accurately reports individual locomotor behavior within the group and that the measurements taken can provide unique insights into the effects of genetic background on individual and group behavior not previously recognized. Expand
Automating mouse weighing in group homecages with Raspberry Pi micro-computers
TLDR
This automated system permits automated weighing of mice ∼40 times per day and employs inexpensive hardware and open-source Python code, and is anticipate integration with tasks where automated imaging or behaviour is assessed in homecages. Expand
An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease
TLDR
Assessment of behavioral changes in male and female R6/2 transgenic mouse models of Huntington's disease shows that the automated behavioral classification software, OpenCage, provides a powerful tool for analyzing natural home-cage mouse behaviors and for constructing behavioral signatures that will be useful for assessing therapeutic strategies. Expand
Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking
TLDR
The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment. Expand
Automated home-cage behavioural phenotyping of mice.
TLDR
A trainable computer vision system enabling the automated analysis of complex mouse behaviours that performs on par with human scoring, as measured from ground-truth manual annotations of thousands of clips of freely behaving mice. Expand
A system utilizing radio frequency identification (RFID) technology to monitor individual rodent behavior in complex social settings
TLDR
An apparatus that uses radio frequency identification device (RFID) technology to facilitate long-term automated monitoring of the behavior of mice in socially or structurally complex cage environments and can be used to quantify validated endophenotypes or biomarkers of these disorders using rodent models is developed. Expand
The power of automated behavioural homecage technologies in characterizing disease progression in laboratory mice: A review
Behavioural changes that occur as animals become sick have been characterized in a number of species and include the less frequent occurrence of ‘luxury behaviours’ such as playing, grooming andExpand
A robust automated system elucidates mouse home cage behavioral structure
TLDR
The utility of the automated approach for the quantitative characterization of fundamental behavioral elements and their patterns in the freely behaving mouse is demonstrated by identifying unique features of home cage behavioral structure and changes in distinct levels of behavioral organization in mice with single gene mutations altering energy balance. Expand
High-throughput automated home-cage mesoscopic functional imaging of mouse cortex
TLDR
A fully automated, open source, self-initiated head-fixation system for mesoscopic functional imaging in mice that provides robust assessment of functional cortical maps on the basis of both spontaneous activity and brief sensory stimuli such as light flashes. Expand
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases
TLDR
A video-based behavior-recognition technology to analyze home-cage behaviors is described and its power is demonstrated by discovering previously unrecognized features of two already extensively characterized mouse models of neurodegenerative disease. Expand
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