Automated quantitative analysis of tissue microarrays reveals an association between high Bcl-2 expression and improved outcome in melanoma.

@article{Divito2004AutomatedQA,
  title={Automated quantitative analysis of tissue microarrays reveals an association between high Bcl-2 expression and improved outcome in melanoma.},
  author={Kyle A Divito and Aaron J. Berger and Robert L. Camp and Marisa P. Dolled-Filhart and David L. Rimm and Harriet M. Kluger},
  journal={Cancer research},
  year={2004},
  volume={64 23},
  pages={
          8773-7
        }
}
The addition of B-cell lymphoma 2 (Bcl-2) antisense to dacarbazine in the treatment of metastatic melanoma demonstrates improved response rates and progression-free survival when compared with dacarbazine alone. Studies on small cohorts of melanoma patients have shown variability in Bcl-2 expression (60%-96% positive). We performed quantitative analysis of Bcl-2 expression in a large patient cohort to assess the association with outcome. Tissue microarrays containing intact melanoma specimens… CONTINUE READING

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