Automated protein model building combined with iterative structure refinement

@article{Perrakis1999AutomatedPM,
  title={Automated protein model building combined with iterative structure refinement},
  author={Anastassis Perrakis and Richard Morris and Victor S. Lamzin},
  journal={Nature Structural Biology},
  year={1999},
  volume={6},
  pages={458-463}
}
In protein crystallography, much time and effort are often required to trace an initial model from an interpretable electron density map and to refine it until it best agrees with the crystallographic data. Here, we present a method to build and refine a protein model automatically and without user intervention, starting from diffraction data extending to resolution higher than 2.3 Å and reasonable estimates of crystallographic phases. The method is based on an iterative procedure that… CONTINUE READING
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New developments in phase refinement Curr

  • J. P. Abrahams, R.A.G. de Graaf
  • Opin. Struct. Biol
  • 1998

Structure of a cephalosporin synthase

  • K Valegard
  • Nature 394,
  • 1998

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