Automated objective determination of percentage of malignant nuclei for mutation testing.

Abstract

Detection of DNA mutations in tumor tissue can be a critical companion diagnostic test before prescription of a targeted therapy. Each method for detection of these mutations is associated with an analytic sensitivity that is a function of the percentage of tumor cells present in the specimen. Currently, tumor cell percentage is visually estimated resulting… (More)
DOI: 10.1097/PAI.0b013e318299a1f6

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