Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds.

Abstract

An automated nanospray system based on chip technology (the NanoMate) was successfully interfaced to a modified Particle Discriminator Interface on a triple quadrupole mass spectrometer. A number of the interface parameters were optimized to improve the sampling efficiency for ions from the chip-based system. Analytical performance was assessed using a number of biochemicals as well as via a methodology for a pharmaceutical that passed validation as required by Good Laboratory Practices. Infusion analyses in flow rates <1 microL/min provided advantages in terms of throughput and sample consumption when compared to other methodologies based on liquid chromatography.

Cite this paper

@article{Corkery2005AutomatedNU, title={Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds.}, author={Leonard J Corkery and Henrianna Pang and Bradley B. Schneider and Thomas R Covey and K. W. Michael Siu}, journal={Journal of the American Society for Mass Spectrometry}, year={2005}, volume={16 3}, pages={363-9} }