Automated multidimensional phenotypic profiling using large public microarray repositories.

@article{Xu2009AutomatedMP,
  title={Automated multidimensional phenotypic profiling using large public microarray repositories.},
  author={Min Xu and Wenyuan Li and Gareth M. James and Michael R. Mehan and Xianghong Jasmine Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 30},
  pages={12323-8}
}
Phenotypes are complex, and difficult to quantify in a high-throughput fashion. The lack of comprehensive phenotype data can prevent or distort genotype-phenotype mapping. Here, we describe "PhenoProfiler," a computational method that enables in silico phenotype profiling. Drawing on the principle that similar gene expression patterns are likely to be associated with similar phenotype patterns, PhenoProfiler supplements the missing quantitative phenotype information for a given microarray… CONTINUE READING
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