Automated mapping of large-scale chromatin structure in ENCODE

@article{Lian2008AutomatedMO,
  title={Automated mapping of large-scale chromatin structure in ENCODE},
  author={Heng Lian and William A. Thompson and Robert E. Thurman and John A. Stamatoyannopoulos and William Stafford Noble and Charles E. Lawrence},
  journal={Bioinformatics},
  year={2008},
  volume={24},
  pages={1911 - 1916}
}
MOTIVATION A recently developed DNaseI assay has given us our first genome-wide view of chromatin structure. In addition to cataloging DNaseI hypersensitive sites, these data allows us to more completely characterize overall features of chromatin accessibility. We employed a Bayesian hierarchical change-point model (CPM), a generalization of a hidden Markov Model (HMM), to characterize tiled microarray DNaseI sensitivity data available from the ENCODE project. RESULTS Our analysis shows that… CONTINUE READING

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