Automated identification of functional dynamic contact networks from X-ray crystallography

@inproceedings{Bedem2013AutomatedIO,
  title={Automated identification of functional dynamic contact networks from X-ray crystallography},
  author={Henry van den Bedem and Gira Bhabha and Kun Yang and Peter E. Wright and James S. Fraser},
  year={2013}
}
NATURE METHODS | ADVANCE ONLINE PUBLICATION | 1 Protein function often depends on the exchange between conformational substates. Allosteric ligand binding or distal mutations can stabilize specific active-site conformations and consequently alter protein function. Observing alternative conformations at low levels of electron density, in addition to comparison of independently determined X-ray crystal structures, can provide mechanistic insights into conformational dynamics. Here we report a new… CONTINUE READING
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