Automated identification of SUMOylation sites using mass spectrometry and SUMmOn pattern recognition software

@article{Pedrioli2006AutomatedIO,
  title={Automated identification of SUMOylation sites using mass spectrometry and SUMmOn pattern recognition software},
  author={Patrick G. A. Pedrioli and Brian Raught and X Zhang and Richard Rogers and J. M. Aitchison and Michael J Matunis and Ruedi Aebersold},
  journal={Nature Methods},
  year={2006},
  volume={3},
  pages={533-539}
}
Tandem mass spectrometry (MS/MS) allows for the rapid identification of many types of post-translational modifications (PTMs), especially those that can be detected by a diagnostic mass shift in one or more peptide fragment ions (for example, phosphorylation). But some PTMs (for example, SUMOs and other ubiquitin-like modifiers) themselves produce multiple fragment ions; combined with fragments from the modified target peptide, a complex overlapping fragmentation pattern is thus generated… CONTINUE READING

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