Automated histamine analysis for in vitro allergy testing. II. Correlation of skin test results with in vitro whole blood histamine release in 82 patients.

@article{Siraganian1977AutomatedHA,
  title={Automated histamine analysis for in vitro allergy testing. II. Correlation of skin test results with in vitro whole blood histamine release in 82 patients.},
  author={Reuben P. Siraganian},
  journal={The Journal of allergy and clinical immunology},
  year={1977},
  volume={59 3},
  pages={
          214-22
        }
}
  • R. Siraganian
  • Published 1 March 1977
  • Medicine, Biology
  • The Journal of allergy and clinical immunology
Histamine‐Dependent Allergy Blood Test
TLDR
There was a significant correlation between skin testing and histamine release in terms of the allergens causing the response, and the measurement of histamine by radioenzymatic technique following its release in blood in response to allergen challenge represents a clinically useful in vitro test for the diagnosis of atopic disease.
Diagnostic value of a glass fibre‐based histamine analysis for allergy testing in children
TLDR
It was found that histamine release was the best single analysis, followed by RAST and prick testing, and it was concluded that the glass fibre‐based histamine analysis, which makes routine histamines release testing possible, is a reliable diagnostic test in children.
A new glass microfibre‐based histamine analysis for allergy testing in children
TLDR
The new microfibre method can provide reproducible, analytically precise (at the nanogram level) histamine release results in pediatric cases where: 1) a positive SPT does not correlate with case history; 2) BPT may be considered too hazardous or inconvenient; 3) confirmation of negative or inconclusive SPT or RAST is needed.
Sensitive Glass Microfibre‐Based Histamine Analysis for Allergy Testing in Washed Blood Cells
TLDR
It was found that the same individuals responded with histamine release to the same allergens in both assays, and the number of responders was almost identical, which substantiated identity between the results obtained by the new microfibre method and the conventional assay.
Effect of allergen-specific immunotherapy on recombinant human interleukin 3-mediated amplification of allergen-induced basophil histamine release.
TLDR
Investigation into decreased histamine release in allergic rhinitis patients treated with specific immunotherapy found it to be a permanent effect of SIT, and short-term SIT does not decrease rhIL-3-mediated amplification of allergen-inducedhistamine release from peripheral blood basophils.
Histamine measurement in whole blood and cell supernatants
TLDR
The data indicate that the double‐antibody RIA (Pharmacia) can be used for studies of basophil histamine release in both whole blood and cell supernatants and the second radioimmunoassay using succinyl‐glycin as an acylating reagent and monoclonal antibodies is the most sensitive assay without any cross‐reactivity with methylhistamine.
Basophil histamine release in the diagnosis of house dust mite and dander allergy of asthmatic children
TLDR
It was found that the histamine release test is a convenient diagnostic method and the study indicates a diagnostic value comparable to the common diagnostic methods in clinical allergy.
Canine leucocyte histamine release: response to antigen and to anti-IgE.
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Determinations of the antigen-neutralizing capacity of allergic sera provide an index of those immunoglobulins in allergic serum which possess anti-anaphylactic properties and are demonstrated to be predictable from the mass action law under the limiting condition of extreme antibody excess.
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A two-step in vitro reaction system has been described for studies with human sera capable of passively sensitizing human leukocytes for interaction with ragweed pollen antigen, and it has been observed that only one in every five nonallergic individuals provides suspensions of leukocyte suitable for passive sensitization.
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An experimental approach to the study of histamine release in allergy suggested itself from observations on anaphylaxis, and it was found that blood cells from sensitized animals released part of their histamine into the plasma when brought into contact in vitro with the antigen.
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IgE antibody measurements may be useful in the assessment of the severity of reaginic allergy in highly sensitive patients and the inverse association between IgE and IgG antiragweed antibodies requires further study.
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