Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.

@article{Uemura2006AutomatedDD,
  title={Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.},
  author={Kazunori Uemura and Atsunori Kamiya and Ichiro Hidaka and Toru Kawada and Shuji Shimizu and Toshiaki Shishido and Makoto Yoshizawa and Masaru Sugimachi and Kenji Sunagawa},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 4},
  pages={
          1278-86
        }
}
Pharmacological support with inotropes and vasodilators to control decompensated hemodynamics requires strict monitoring of patient condition and frequent adjustments of drug infusion rates, which is difficult and time-consuming, especially in hemodynamically unstable patients. To overcome this difficulty, we have developed a novel automated drug delivery system for simultaneous control of systemic arterial pressure (AP), cardiac output (CO), and left atrial pressure (Pla). Previous systems… 
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24 Citations
Background Citations
9
Methods Citations
6

24 Citations

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Citation Type

Automated drug delivery system for the management of hemodynamics and cardiac energetic in acute heart failure
TLDR
By directly controlling the mechanical properties of the heart and vessel, the automated system realizes comprehensive management of hemodynamics in acute heart failure and enables to improve cardiac energetic efficiency while preserving AP, CO, and PLA within acceptable ranges.
Less Invasive and Inotrope-Reduction Approach to Automated Closed-Loop Control of Hemodynamics in Decompensated Heart Failure
TLDR
In a minimally invasive setting while reducing the use of inotrope, the automated drug infusion system succeeded in automatically optimizing the overall hemodynamics in canine models of HF.
Automated Cardiovascular Drug Infusion System to Control Hemodynamics
TLDR
A novel approach to control overall hemodynamics is introduced and several closed-loop systems to automate drug infusion are introduced to address issues in their clinical application and discuss future perspectives in this field.
Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock
TLDR
In a canine model of endotoxin shock, a computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock automatically improved and maintained AP and CO at their target values with small performance error.
Development of an automated closed-loop β-blocker delivery system to stably reduce myocardial oxygen consumption without inducing circulatory collapse in a canine heart failure model: a proof of concept study
TLDR
The feasibility of an automated β-blocker administration system in a canine model of acute HF is demonstrated, and the system controlled AP and PLA to avoid circulatory collapse, and reduced MVO2 significantly.
Computationally Managed Bradycardia Improved Cardiac Energetics While Restoring Normal Hemodynamics in Heart Failure
TLDR
In a canine acute heart failure model, computationally managed bradycardia improved cardiac energetic efficiency while restoring normal hemodynamic conditions.
Reduction of myocardial oxygen demand by controlling heart rate and hemodynamics simultaneously by novel circulatory model
TLDR
In 7 dogs with acute heart failure, the treatment for hemodynamics alone and the addition of bradycardia decreased cardiac oxygen consumption, and it was possible to maintain hemodynamics without sacrificing cardiacoxy consumption.
Comprehensive Physiological Cardiovascular Model Enables Automatic Correction of Hemodynamics in Patients with Acute Life-Threatening Heart Failure
TLDR
A comprehensive physiological cardiovascular model is established, on which the design of the autopilot system is based, which is able to correct blood pressure, cardiac output, and left atrial pressure to the target values rapidly and stably.
Low-Dose Landiolol Reduces Heart Rate and Cardiac Oxygen Consumption Without Compromising Initial Hemodynamic Resuscitation in a Canine Model of Endotoxin Shock.
TLDR
Low-dose landiolol may reduce HR without compromising initial hemodynamic resuscitation in septic shock, to clearly establish this, large-size randomized study using animal models more relevant to septicshock is needed.
Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs
TLDR
A comprehensive physiological cardiovascular model enabled us to evaluate cardiovascular properties (pump function, vascular resistance, and blood volume) and the feedback control of these properties and in 12 dogs, rapid, sufficient and stable control of pump function,ascular resistance andBlood volume was achieved.
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