Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease

@article{Leung2010AutomatedCA,
  title={Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease},
  author={Kelvin K. Leung and Josephine Barnes and Gerard R. Ridgway and Jonathan W. Bartlett and Matthew J. Clarkson and Kate E. Macdonald and Norbert Schuff and Nick C. Fox and S{\'e}bastien Ourselin},
  journal={NeuroImage},
  year={2010},
  volume={51 4},
  pages={1345-59}
}
Volume and change in volume of the hippocampus are both important markers of Alzheimer's disease (AD). Delineation of the structure on MRI is time-consuming and therefore reliable automated methods are required. We describe an improvement (multiple-atlas propagation and segmentation (MAPS)) to our template library-based segmentation technique. The improved technique uses non-linear registration of the best-matched templates from our manually segmented library to generate multiple segmentations… CONTINUE READING
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