Automated column liquid chromatographic determination of amoxicillin and cefadroxil in bovine serum and muscle tissue using on-line dialysis for sample preparation.

@article{Snippe1994AutomatedCL,
  title={Automated column liquid chromatographic determination of amoxicillin and cefadroxil in bovine serum and muscle tissue using on-line dialysis for sample preparation.},
  author={N Snippe and Nico C van de Merbel and F P Ruiter and Odile M Steijger and Henk Lingeman and Udo A Th Brinkman},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1994},
  volume={662 1},
  pages={61-70}
}
A fully automated method is described for the determination of amoxicillin and cefadroxil in bovine serum and muscle tissue. The method is based on the on-line combination of dialysis and solid-phase extraction for sample preparation, and column liquid chromatography with ultraviolet detection. In order to enhance the UV detectability of the analytes, post-column addition of 0.1 M sodium hydroxide is performed. The method shows good linearity and repeatability for both analytes in serum as well… CONTINUE READING