Corpus ID: 16974200

Automated blood sampling in drug discovery and development

  title={Automated blood sampling in drug discovery and development},
  author={Sven Deferme},
2 Citations
Utilization of Mouse Automated Blood Sampling (ABS) for Serial Plasma Pharmacokinetic (PK) Studies
In response to the increased demand for rodent PK data in the scientific industry, automated blood sampling (ABS) has now provided the capability to serial microsample blood from mice. It usesExpand
Blood microsampling using capillaries for drug-exposure determination in early preclinical studies: a beneficial strategy to reduce blood sample volumes.
CMS in 15 µl glass capillaries allows collection and handling of small and exact volumes of blood, and the full benefit is only achieved with blood collection and analysis. Expand


A comparative study of the pharmacokinetics of traditional and automated dosing/blood sampling systems using gabapentin
The described ADI/ABS method was found to be a useful drug development tool for accelerating the pace of preclinical in vivo studies and for obtaining reliable and accurate PK parameters even from single animals as it minimized interanimal and physiological variations. Expand
An integrative pharmacological approach to radio telemetry and blood sampling in pharmaceutical drug discovery and safety assessment
The ABST system provides opportunities to evaluate temporal relations between parameters and to investigate anomalous outlier events because drug concentrations, physiological and biochemical measures for each animal are available for comparisons. Expand
Application of automated serial blood sampling and dried blood spot technique with liquid chromatography-tandem mass spectrometry for pharmacokinetic studies in mice.
The results indicated that the automated blood sampling system and DBS collection are promising techniques to obtain full pharmacokinetic profiles from individual mice and reduce the use of animals. Expand
Combining radio telemetry and automated blood sampling: a novel approach for integrative pharmacology and toxicology studies.
These studies demonstrate for the first time that drug-induced PD responses can be recorded simultaneously with time-matched pharmacokinetic, biochemical and metabolic parameters in the same animal. Expand
A blood sampling microsystem for pharmacokinetic applications: design, fabrication, and initial results.
This paper describes a microsystem for automated blood sampling from laboratory mice used in pharmacokinetic studies that uses a microneedle, reservoir, and an actuator to instantaneously prick the animal for a time-point sample, eliminating the need for a tethered catheter with large dead volume. Expand
An Automated Discontinuous Venous Blood Sampling System for Ex Vivo Glucose Determination in Humans
The study showed that the ABS system described provides a user-friendly, reliable automated means for reproducible and accurate blood sampling from a peripheral vein for blood glucose determination and thus represents a promising alternative to frequent manual blood sampling. Expand
Development of an automated blood sampling system for use in humans
The ability of the system to allow multiple measurements and of the software program to link with other physiological monitoring equipment provides a powerful tool to study physiologic/pathophysiologic change in relation to blood hormone and other biomarker levels. Expand
Automated Blood Sampling and Glucose Sensing in Critical Care Settings
Cascade's automated peripheral venous blood sampling system, in combination with a flow-through glucose sensor system, offers several advantages over current state-of-the-art systems, including the potential for significantly improved workflow in the ICU, minimal discomfort to the patient, and accurate glucose measurement in whole blood, thus helping achieve tight glycemic control. Expand
An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents.
The applicability of intracerebral microdialysis combined with arterial blood sampling was demonstrated for simultaneous PK/PD investigations of escitalopram in individual rats under non-stressful conditions, hence minimizing inter-animal variation using a reduced number of animals. Expand
Bioavailability of salvianolic acid B in conscious and freely moving rats.
Intra- and inter-assay precision and accuracy of salvianolic acid B fell well within the predefined limits of acceptability (<15%) and the oral bioavailability in freely moving rats was calculated to be 2.3%. Expand