Automated and assisted RNA resonance assignment using NMR chemical shift statistics

  title={Automated and assisted RNA resonance assignment using NMR chemical shift statistics},
  author={Thomas Aeschbacher and Elena Schmidt and Markus Blatter and Christophe Maris and Olivier Duss and Fr{\'e}d{\'e}ric H.-T. Allain and Peter G{\"u}ntert and Mario Schubert},
  booktitle={Nucleic acids research},
The three-dimensional structure determination of RNAs by NMR spectroscopy relies on chemical shift assignment, which still constitutes a bottleneck. In order to develop more efficient assignment strategies, we analysed relationships between sequence and (1)H and (13)C chemical shifts. Statistics of resonances from regularly Watson-Crick base-paired RNA revealed highly characteristic chemical shift clusters. We developed two approaches using these statistics for chemical shift assignment of… CONTINUE READING
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