Automated 96-well liquid-liquid back extraction liquid chromatography-tandem mass spectrometry method for the determination of ABT-202 in human plasma.

@article{Xu2004Automated9L,
  title={Automated 96-well liquid-liquid back extraction liquid chromatography-tandem mass spectrometry method for the determination of ABT-202 in human plasma.},
  author={Naxing Xu and G. Kim and H. Gregg and Azza M Wagdy and Brendan A Swaine and M. S. Chang and T. El-Shourbagy},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2004},
  volume={36 1},
  pages={
          189-95
        }
}
A high-throughput bioanalytical method using automated sample transferring, automated liquid-liquid back extraction and liquid chromatography-tandem mass spectrometry was developed in a GLP regulated environment for the determination of ABT-202 in human plasma. Samples of 0.30 ml were transferred into 96-well plate using an automatic liquid handler. Automated liquid-liquid extraction (LLE) was carried out on a 96-channel programmable liquid handling workstation using methyl tert-butyl ether as… Expand
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