Automated 24-hours sampling of subcutaneous tissue free cortisol in humans.

  title={Automated 24-hours sampling of subcutaneous tissue free cortisol in humans.},
  author={Ragini Bhake and Jack A. Leendertz and Astrid C. E. Linthorst and Stafford L. Lightman},
  journal={Journal of medical engineering & technology},
  volume={37 3},
Hormonal systems are major regulators of metabolic and cognitive function and many of these, including the critical stress-responsive hypothalamic-pituitary-adrenal (HPA) axis, release their constituent hormones in a circadian manner. This circadian rhythmicity is made up from an underlying approximate hourly ultradian rhythm. In order to understand the importance of both circadian and ultradian rhythms in man it is important to be able to carry out multiple sampling studies over extended… CONTINUE READING
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