Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro.

@article{Schultze1997AutologousTI,
  title={Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro.},
  author={Joachim L. Schultze and Matthew J. Seamon and Sabine Michalak and John G Gribben and Lee M. Nadler},
  journal={Blood},
  year={1997},
  volume={89 10},
  pages={
          3806-16
        }
}
Follicular lymphomas (FLs) rarely induce clinically significant T-cell-mediated responses. We showed that freshly isolated tumor infiltrating T cells (T-TILs) lack tumor-specific cytotoxicity. Stimulation of these T cells with FL cells in the presence of interleukin-2 (IL-2) and/or costimulation via CD28 does not lead to T-cell activation and expansion. In contrast, when stimulated with FL cells preactivated via CD40, autologous T-TILs can be expanded by the addition of exogenous IL-2. These T… CONTINUE READING
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