Autologous stem cell transplantation for high-risk pediatric solid tumors

@article{Perentesis1999AutologousSC,
  title={Autologous stem cell transplantation for high-risk pediatric solid tumors},
  author={J P Perentesis and Emmanuel Katsanis and T Defor and J Neglia and N K C Ramsay},
  journal={Bone Marrow Transplantation},
  year={1999},
  volume={24},
  pages={609-615}
}
Many solid tumors exhibit a steep dose-response to alkylating agents, and autologous stem cell transplantation (ASCT) allows escalation of the chemotherapy dose for treatment of high risk solid tumors. We have transplanted 24 children and young adults with relapsed or metastatic solid tumors on two consecutive ASCT protocols consisting primarily (protocol MT 8911) or exclusively (MT 9408) of alkylating agents. The median time to neutrophil engraftment was 21 days in protocol MT 8911 (no… CONTINUE READING

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