Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life

@article{Casabona2017AutologousPP,
  title={Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life},
  author={Francesco Casabona and Ilaria Gambelli and Federica Casabona and Pierluigi Santi and Gregorio Santori and Ilaria Baldelli},
  journal={International Urology and Nephrology},
  year={2017},
  volume={49},
  pages={573-580}
}
PurposeLichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. [...] Key Method The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS.MethodsForty-five male patients affected by penile LS underwent injections of autologous PRP in the affected skin areas.Expand
Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report
The use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus (LS) in a 38-year-old premenopausal woman is reported. The diagnosis was confirmed histologically and the symptomsExpand
Platelet-rich plasma for genital lichen sclerosus: analysis and results of 94 patients. Are there gender-related differences in symptoms and therapeutic response to PRP?
TLDR
It is demonstrated that PRP based therapy may exert a relevant role in LS patient management due to its effect on Quality of Life (QoL), sexual function in both gender, and gender-related differences in severity of symptoms and disease age onset. Expand
The use of PRP (platelet‐rich plasma) in patients affected by genital lichen sclerosus: clinical analysis and results
TLDR
The aim of this study is to evaluate the efficacy of platelet-rich-plasma(PRP) treatment in LS patients and to suggest a new therapeutic option to treat this class of patients. Expand
Platelet‐rich plasma for male genital lichen sclerosus resistant to conventional therapy: First prospective study
TLDR
TPRP seems to be safe and effective, regarding symptom control and improvement in QoL; however, visual changes were minimal. Expand
Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus
TLDR
Current evidence is weak for ADSCs and/or PRP as treatment for vulvar LS, and further research is needed before recommending this therapy. Expand
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TLDR
The aim of this review was to analyze the literature on the mechanisms of PRP action in patients with dermatological diseases. Expand
Improvement of rosacea by injection of platelet-rich plasma
TLDR
In conclusion, PRP enriched with CD34 stem cells in the peripheral blood may have a potential additive therapeutic effect on rosacea via an immunomodulation effect. Expand
Diagnosis and management of cutaneous and anogenital lichen sclerosus: recommendations from the Italian Society of Dermatology (SIDeMaST).
TLDR
Surgical treatment has become the treatment of choice in male genital LS with persistent phimosis not responsive to medical treatment and the highest level of evidence favors the use of topical high potency corticosteroids. Expand
Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study
TLDR
The injection of A-PRP-HA appeared to be a promising method to improve the trophicity and hydration of vaginal mucosa for the treatment of VVA in postmenopausal breast cancer survivors with contraindications to hormone therapy. Expand
Use of autologous platelet-rich plasma in treatment of genital forms of scleroatrophic lichen
The article provides an overview of the use of platelet-rich plasma (PRP) for the treatment of lichen sclerosis (LS). The definition, principle of operation and main characteristics of this methodExpand
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