Autologous mesenchymal stem cells mobilize cKit+ and CD133+ bone marrow progenitor cells and improve regional function in hibernating myocardium.

@article{Suzuki2011AutologousMS,
  title={Autologous mesenchymal stem cells mobilize cKit+ and CD133+ bone marrow progenitor cells and improve regional function in hibernating myocardium.},
  author={Gen Suzuki and Vijay K. Iyer and Te-Chung Lee and John M. Canty},
  journal={Circulation research},
  year={2011},
  volume={109 9},
  pages={1044-54}
}
RATIONALE Mesenchymal stem cells (MSCs) improve function after infarction, but their mechanism of action remains unclear, and the importance of reduced scar volume, cardiomyocyte proliferation, and perfusion is uncertain. OBJECTIVE The present study was conducted to test the hypothesis that MSCs mobilize bone marrow progenitor cells and improve function by stimulating myocyte proliferation in collateral-dependent hibe rnating myocardium. METHODS AND RESULTS Swine with chronic hibernating… CONTINUE READING

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Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ hematopoietic progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle

  • G Suzuki, V Iyer, T Cimato, JM Canty, Jr.
  • Circ Res
  • 2009

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