Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results

@inproceedings{Bowen2012AutologousHC,
  title={Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results},
  author={J D Bowen and George Howard Kraft and Annette Wundes and Qingyan Guan and Kenneth R. Maravilla and Theodore A Gooley and Peter A. Mcsweeney and Steven Z Pavletic and Harry Openshaw and Rainer F Storb and Mark H. Wener and Bernadette A. McLaughlin and Gretchen R. Henstorf and Richard A. Nash},
  booktitle={Bone Marrow Transplantation},
  year={2012}
}
The purpose of the study was to determine the long-term safety and effectiveness of high-dose immunosuppressive therapy (HDIT) followed by autologous hematopoietic cell transplantation (AHCT) in advanced multiple sclerosis (MS). TBI, CY and antithymocyte globulin were followed by transplantation of autologous, CD34-selected PBSCs. Neurological examinations, brain magnetic resonance imaging and cerebrospinal fluid (CSF) for oligoclonal bands (OCB) were serially evaluated. Patients (n=26, mean… CONTINUE READING
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