Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas

@article{Okada2007AutologousGC,
  title={Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas},
  author={Hideho Okada and Frank Lieberman and Kevin A. Walter and L D Lunsford and Douglas Kondziolka and Ghassan K. Bejjani and Ronald L. Hamilton and Alejandro Torres-Trejo and Pawel Kalinski and Quan Cai and Jennifer L Mabold and Howard D. Edington and Lisa H Butterfield and Theresa L Whiteside and Douglas M. Potter and S. Clifford Schold and Ian F Pollack},
  journal={Journal of Translational Medicine},
  year={2007},
  volume={5},
  pages={67 - 67}
}
The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfected fibroblasts. In University of Pittsburgh Cancer Institute (UPCI) protocol 95-033, adult participants with recurrent glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA) received gross total resection (GTR) of the recurrent tumors, followed by two vaccinations with autologous… CONTINUE READING
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