Autologous full-thickness skin substitute for healing chronic wounds.

  title={Autologous full-thickness skin substitute for healing chronic wounds.},
  author={Susan Gibbs and Henk M van den Hoogenband and Gudula Kirtschig and Cornelia D. Richters and Sander W. Spiekstra and Melanie Breetveld and Rik J. Scheper and Edith M de Boer},
  journal={The British journal of dermatology},
  volume={155 2},
BACKGROUND Chronic wounds represent a major problem to our society. Therefore, advanced wound-healing strategies for the treatment of these wounds are expanding into the field of tissue engineering. OBJECTIVES To develop a novel tissue-engineered, autologous, full-thickness skin substitute of entirely human origin and to determine its ability to heal chronic wounds. METHODS Skin substitutes (fully differentiated epidermis on fibroblast-populated human dermis) were constructed from 3-mm… CONTINUE READING

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