Fat augmentation is safe, relatively inexpensive, and readily available. Now that cosmetic surgeons are recognizing that facial aging is not simply due to gravity but also to atrophy of tissues, the use of fat for volume restoration is becoming even more popular. Newer techniques of Lipostructure, facial fat rebalancing, and fat autograft muscle injection (FAMI) are targeted to achieve true full-face three-dimensional rejuvenation; however, practical means of objectively measuring outcome are lacking. Basic questions remain regarding the optimal harvesting site, processing technique, and most effective injection technique. Scientific research is emerging th address these issues.