Autologous bone-marrow stem-cell transplantation for myocardial regeneration

  title={Autologous bone-marrow stem-cell transplantation for myocardial regeneration},
  author={Christof Stamm and Bernd Westphal and Hans Dieter Kleine and Michael Petzsch and Prof. Dr. med. Gustav Steinhoff},
  journal={The Lancet},
Intramyocardial bone marrow stem cell treatment for myocardial regeneration
The current knowledge on the mechanisms involved in regenerative potential of bone-marrow-derived stem cells, with special attention to the clinical experience with cell transplantation during cardiac surgery, is summarized.
Autologous bone marrow-derived progenitor cell transplantation for myocardial regeneration after acute infarction.
Preliminary results of the study showed that the transplantation of bone marrow-derived progenitor cells into the infarcted area was safe, and feasible, and might improve myocardial function.
Bone marrow stem cells in the infarcted heart.
Some interesting aspects of the fast emerging field of bone marrow derived stem cell therapy for cardiac repair are reviewed.
Transplant of autologous bone marrow stem cells in ischemic heart disease
Early clinical trials have shown that implantation of autologous bone marrow cells Transplant of autologies bone marrow stem cells in ischemic heart disease is safe and effective.
Host Vascular Niche Contributes to Myocardial Repair Induced by Intracoronary Transplantation of Bone Marrow CD34+ Progenitor Cells in Infarcted Swine Heart
The data suggest that existence of intrinsic collateral vessels contributes greatly to the beneficial effects of intracoronary BMT on cardiac repairs after MI.
Myocardial Regeneration: Which Cell and Why
Treatment of damaged myocardium after myocardial infarction by cell transplantation is becoming an increasingly promising therapeutic approach. Ideally, the donor cells should be amplified
Stem cell research and cell transplantation for myocardial regeneration.


Bone marrow cells regenerate infarcted myocardium
It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Cardiomyocyte transplantation improves heart function.
Myoblast transplantation for heart failure
Origin of endothelial progenitors in human postnatal bone marrow.
Because MAPCs can be expanded in culture without obvious senescence for more than 80 population doublings, they may be an important source of endothelial cells for cellular pro- or anti-angiogenic therapies.