Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children.

@article{Liao2015AutologousBM,
  title={Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children.},
  author={George P. Liao and Matthew T Harting and Robert A. Hetz and Peter A. Walker and Shinil K Shah and Christopher J Corkins and Travis G. Hughes and Fernando Jim{\'e}nez and Steven C Kosmach and M M Day and Kuojen Tsao and Amanda J Lee and Laura L. Worth and James E. Baumgartner and Charles S. Cox},
  journal={Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies},
  year={2015},
  volume={16 3},
  pages={245-55}
}
OBJECTIVES The devastating effect of traumatic brain injury is exacerbated by an acute secondary neuroinflammatory response, clinically manifest as elevated intracranial pressure due to cerebral edema. The treatment effect of cell-based therapies in the acute post-traumatic brain injury period has not been clinically studied although preclinical data demonstrate that bone marrow-derived mononuclear cell infusion down-regulates the inflammatory response. Our study evaluates whether pediatric… CONTINUE READING
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