Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats.

@article{Brenneman2010AutologousBM,
  title={Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats.},
  author={Miranda M Brenneman and Sushil Sharma and Matthew T Harting and Roger Strong and Charles S. Cox and Jarek Aronowski and James C. Grotta and Sean Isaac Savitz},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2010},
  volume={30 1},
  pages={140-9}
}
We investigated intra-arterially administered autologous bone marrow mononuclear cells (MNCs) in rats with acute ischemic stroke. Long Evans rats (2 to 3 months or 12 months old) underwent tandem reversible common carotid artery (CCA)/middle cerebral artery (MCA) occlusion (CCAo/MCAo) for 3 h and then 24 h later underwent tibial bone marrow harvest. Ten million or 4 million cells were re-injected by an intra-carotid infusion. Control animals underwent marrow needle insertion and then saline… CONTINUE READING
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