Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model
@article{Sun2011AutologousTO, title={Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model}, author={C. Sun and Chia-Hung Yen and Y. Lin and T. Tsai and L. Chang and Ying-Hsien Kao and S. Chua and M. Fu and S. Ko and S. Leu and H. Yip}, journal={Journal of Translational Medicine}, year={2011}, volume={9}, pages={118 - 118} }
BackgroundThis study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury.MethodsAdult male Sprague-Dawley (SD) rats (n = 24) were equally randomized into group 1 (sham control), group 2 (IR plus culture medium only), and group 3 (IR plus intravenous transplantation of 1.5 × 106 autologous ADMSCs at 1h, 6h, and 24h following IR injury). The duration of ischemia was 30… CONTINUE READING
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