Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model

@inproceedings{Sun2011AutologousTO,
  title={Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model},
  author={Cheuk-Kwan Sun and Chia-Hung Yen and Yu-Chun Lin and Tzu-hsien Tsai and Li-Teh Chang and Ying-Hsien Kao and Sarah Tze Chuen Chua and Morgan Fu and S{\"o}derstr{\"o}m Ko and Steve Leu and Hon-Kan Yip},
  booktitle={Journal of Translational Medicine},
  year={2011}
}
BackgroundThis study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury.MethodsAdult male Sprague-Dawley (SD) rats (n = 24) were equally randomized into group 1 (sham control), group 2 (IR plus culture medium only), and group 3 (IR plus intravenous transplantation of 1.5 × 106 autologous ADMSCs at 1h, 6h, and 24h following IR injury). The duration of ischemia was 30… CONTINUE READING
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