Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.

@article{Hawkey2015AutologousHS,
  title={Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.},
  author={Christopher J. Hawkey and Matthieu Allez and Miranda M Clark and Myriam Labopin and James O. Lindsay and Elena Ricart and Gerhard Rogler and Montserrat Rovira and Jack Satsangi and Silvio Danese and Nigel H. Russell and John G. Gribben and Peter E. Johnson and J{\'e}rome Largh{\'e}ro and Catherine Thieblemont and Sandro Ardizzone and Daan Dierickx and Adalberto Ibatici and Timothy J Littlewood and Francesco Onida and Urs Schanz and S{\'e}verine Vermeire and Jean-Fr{\'e}d{\'e}ric Colombel and Jean-Paul Jouet and Elizabeth H Clark and Riccardo Saccardi and Alan Tyndall and Simon P L Travis and Dominique Farge},
  journal={JAMA},
  year={2015},
  volume={314 23},
  pages={
          2524-34
        }
}
  • Christopher J. Hawkey, Matthieu Allez, +26 authors Dominique Farge
  • Published in JAMA 2015
  • Medicine
  • IMPORTANCE Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. OBJECTIVE To evaluate the effect of autologous HSCT on refractory Crohn disease. DESIGN, SETTING, AND PARTICIPANTS Parallel-group randomized clinical trial conducted in 11 European transplant units from July 2007 to September 2011, with follow-up through March 2013. Patients were aged 18 to 50 years with impaired quality of life from refractory Crohn… CONTINUE READING

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