Autoinhibition of human dicer by its internal helicase domain.

  title={Autoinhibition of human dicer by its internal helicase domain.},
  author={Enbo Ma and Ian J MacRae and Jack F. Kirsch and Jennifer A. Doudna},
  journal={Journal of molecular biology},
  volume={380 1},
Dicer, a member of the ribonuclease III family of enzymes, processes double-stranded RNA substrates into approximately 21- to 27-nt products that trigger sequence-directed gene silencing by RNA interference. Although the mechanism of RNA recognition and length-specific cleavage by Dicer has been established, the way in which dicing activity is regulated is unclear. Here, we show that the N-terminal domain of human Dicer, which is homologous to DExD/H-box helicases, substantially attenuates the… CONTINUE READING
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