Autoinhibition of endothelial nitric oxide synthase (eNOS) in gut smooth muscle by nitric oxide

  title={Autoinhibition of endothelial nitric oxide synthase (eNOS) in gut smooth muscle by nitric oxide},
  author={J. Grider and K. Murthy},
  journal={Regulatory Peptides},
Nitric oxide in the gut is produced by nNOS in enteric neurons and by eNOS in smooth muscle cells. The eNOS in smooth muscle is activated by vasoactive intestinal peptide (VIP) released from enteric neurons. In the present study, we examined the effect of nitric oxide on VIP-induced eNOS activation in smooth muscle cells isolated from human intestine and rabbit stomach. NOS activity was measured as formation of the 1:1 co-product, l-citrulline from l-arginine. VIP caused an increase in l… Expand
Vasoactive intestinal polypeptide relaxes isolated rat pulmonary artery rings through two distinct mechanisms
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Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
Chronic alcohol consumption induces an overproduction of NO by nNOS‐ and iNOS‐expressing myenteric neurons in the murine small intestine
  • M. Bagyánszki, P. Torfs, +5 authors A. Kroese
  • Biology, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2011
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Regulation of nitric oxide synthase by nitric oxide.
Inhibitory effects of nitric oxide donors on nitric oxide synthesis in rat gastric myenteric plexus.