Corpus ID: 27977602

Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.

@article{Chinmayee1988AutoinhibitionAD,
  title={Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.},
  author={N Chinmayee and D. P. Joshi and Anita A. Mehta and Ramesh K Goyal},
  journal={Indian journal of physiology and pharmacology},
  year={1988},
  volume={32 3},
  pages={
          215-20
        }
}
The present study was undertaken to investigate the autoinhibition and desensitization of 5-hydroxytryptamine (5-HT) using another agonist MK-212 on guinea pig ileum. 5-HT and MK-212 produced dose dependent contractions of guinea pig ileum. The responses to MK-212 were reduced in the presence of 5-HT and vice versa. Neither 5-HT nor MK-212 produced any change in the responses to histamine, acetylcholine or KCl. Increase in Ca++ in bathing fluid reversed the desensitization produced by MK-212 or… Expand

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