Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.

@article{Chinmayee1988AutoinhibitionAD,
  title={Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.},
  author={N Chinmayee and Darshana Pathak Joshi and Anita A. Mehta and Ramesh K. Goyal},
  journal={Indian journal of physiology and pharmacology},
  year={1988},
  volume={32 3},
  pages={215-20}
}
The present study was undertaken to investigate the autoinhibition and desensitization of 5-hydroxytryptamine (5-HT) using another agonist MK-212 on guinea pig ileum. 5-HT and MK-212 produced dose dependent contractions of guinea pig ileum. The responses to MK-212 were reduced in the presence of 5-HT and vice versa. Neither 5-HT nor MK-212 produced any… CONTINUE READING