Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

@article{Torisawa2014AutoinhibitionAC,
  title={Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein},
  author={Takayuki Torisawa and Muneyoshi Ichikawa and Akane Furuta and Kei Saito and Kazuhiro Oiwa and Hiroaki Kojima and Yoko Yano Toyoshima and Ken’ya Furuta},
  journal={Nature Cell Biology},
  year={2014},
  volume={16},
  pages={1118-1124}
}
Cytoplasmic dynein is a two-headed microtubule-based motor responsible for diverse intracellular movements, including minus-end-directed transport of organelles. The motility of cargo transporters is regulated according to the presence or absence of cargo; however, it remains unclear how cytoplasmic dynein achieves such regulation. Here, using a recombinant and native dynein complex in vitro, we show that lone, single dynein molecules are in an autoinhibited state, in which the two motor heads… CONTINUE READING
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