Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1.

@article{Xu2009AutoinhibitionAA,
  title={Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1.},
  author={Yong-jie Xu and Thomas Joseph Kelly},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 23},
  pages={
          16016-27
        }
}
Cds1 is the ortholog of Chk2 and the major effector of the DNA replication checkpoint in Schizosaccharomyces pombe. Previous studies have shown that Cds1 is activated by a two-stage mechanism. In the priming stage, the sensor kinase Rad3 and the mediator Mrc1 function to phosphorylate a threonine residue, Thr(11), in the SQ/TQ domain of Cds1. In the autoactivation stage, primed Cds1 molecules dimerize via intermolecular interactions between the phosphorylated Thr(11) in one Cds1 and the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

1999)Current Protocols in Molecular Biology, pp. 18.9.1–18.9.28

J. Meisenhelder, T. Hunter, P. van der Geer
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Autoinhibition and Autoactivation

J. Y. Ahn, X. Li, H. L. Davis, C. E. Canman
  • J. Biol. Chem
  • 2002
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…