Autoinhibition and adapter function of Syk.

@article{Kulathu2009AutoinhibitionAA,
  title={Autoinhibition and adapter function of Syk.},
  author={Yogesh Kulathu and Gesina Grothe and Michael Reth},
  journal={Immunological reviews},
  year={2009},
  volume={232 1},
  pages={
          286-99
        }
}
Development, survival, and activation of B lymphocytes are controlled by signals emanating from the B-cell antigen receptor (BCR). The BCR has an autonomous signaling function also known as tonic signaling that allows for long-term survival of B cells in the immune system. Upon binding of antigen to the BCR, the tonic signal is amplified and diversified, leading to alteration in gene expression and B-cell activation. The spleen tyrosine kinase (Syk) intimately cooperates with the signaling… CONTINUE READING

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