Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element.

@article{Bulitta2002AutoinductionOT,
  title={Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element.},
  author={Clemens J. Bulitta and John V. Fleming and Raktima Raychowdhury and Douglas R. Taupin and I. Richard Rosenberg and Timothy C Wang},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={293 1},
  pages={366-74}
}
Trefoil factor 2 (TFF2)/spasmolytic polypeptide (SP) is a highly stable peptide which is abundantly expressed and secreted by mucous cells of the stomach and which functions in gastric cytoprotection. Previous studies from our group have shown that TFF2 is an immediate early gene capable of regulating its own expression through activation of the TFF2 promoter. We therefore aimed to investigate the cis-acting elements mediating this response in AGS cells transfected with TFF2 promoter-reporter… CONTINUE READING
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