Autoinducer production and quorum-sensing dependent phenotypes of Pseudomonas aeruginosa vary according to isolation site during colonization of intubated patients

@article{FavreBont2006AutoinducerPA,
  title={Autoinducer production and quorum-sensing dependent phenotypes of Pseudomonas aeruginosa vary according to isolation site during colonization of intubated patients},
  author={Sabine Favre-Bont{\'e} and Eric A M Chamot and Thilo K{\"o}hler and J L Romand and Christian van Delden},
  journal={BMC Microbiology},
  year={2006},
  volume={7},
  pages={33 - 33}
}
Pseudomonas aeruginosa frequently colonizes and is responsible for severe ventilator-associated pneumonia in intubated patients. A quorum-sensing (QS) circuit, depending on the production of the two QS-signaling molecules (autoinducers, AIs) 3-oxo-C12-HSL and C4-HSL, regulates the production by P. aeruginosa of several virulence factors and is required for biofilm formation. Therefore QS-inhibition has been suggested as a new target for preventive and/or therapeutic strategies. However the… CONTINUE READING