Autoimmunity versus horror autotoxicus: The struggle for recognition

  title={Autoimmunity versus horror autotoxicus: The struggle for recognition},
  author={A. M. Silverstein},
  journal={Nature Immunology},
Why is it that certain indisputable facts in science may be so effaced from the collective memory that they must be discovered anew, even many decades later? Was Paul Ehrlich’s demonstration in 1892 of the passive transfer of antibody from mother to fetus and neonate so unclear—or Clemens von Pirquet’s explanation of the pathogenesis of immune complex disease in 1910 so incomplete—that full acceptance of the phenomena had to await a repeat of the experiments 50–60 years later? I shall point out… CONTINUE READING