Autoimmunity versus horror autotoxicus: The struggle for recognition

@article{Silverstein2001AutoimmunityVH,
  title={Autoimmunity versus horror autotoxicus: The struggle for recognition},
  author={A. M. Silverstein},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={279-281}
}
Historical insight: Paul Ehrlich's dictum of horror autotoxicus and the changing orientation of the field inhibited acceptance of the reality of autoimmune disease. 

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For over 75 years, only humoral antibodies were known to mediate immunological specificity. The apparent absence of these in delayed-type hypersensitivity reactions was perplexing, and the dominant

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    Proceedings of the National Academy of Sciences
  • 2015
With all of the certainty of death and taxes, questions regarding the mechanisms of immunological tolerance remain fixtures across the landscape of immunology. From Paul Ehlirch’s “horror

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Discussion on changes in gut microbiota driving the breakdown of mucosal barrier in NOD mice; the resulting inflammation and impairment of oral tolerance induces the autoimmune diabetes.

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The development of antibody-producing B cells and B cell self-tolerance in humans and the role of CD inhibition in this process are described.

Do autoantigens define autoimmunity or vice versa?

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    European journal of immunology
  • 2005
The overall paradigm of autoimmunity is discussed, and it is likely that multiple different pathways are critical in various diseases, and even in a single condition.

The Recent History of Tumour Necrosis Factor (TNF)

The participants provide insights into how TNF has become a focal point for the study of inflammatory and malignant diseases, and discuss the obstacles and the opportunities that arose during the development of anti-TNF drugs.

RAGs and regulation of autoantibodies.

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Chimeric Antigen Receptor Therapy.

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The anti-DNA antibody: origin and impact, dogmas and controversies

  • O. Rekvig
  • Medicine, Biology
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  • 2015
The inclusion of 'the anti-DNA antibody' by the ACR and the Systemic Lupus International Collaborating Clinics as a criterion for systemic lupus erythematosus does not convey the diverse origins of these antibodies, the specificities exerted by these antibodies or their clinical impact—or lack thereof.
...

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