Autoimmunity to the Sodium-Level Sensor in the Brain Causes Essential Hypernatremia

@article{Hiyama2010AutoimmunityTT,
  title={Autoimmunity to the Sodium-Level Sensor in the Brain Causes Essential Hypernatremia},
  author={Takeshi Y. Hiyama and Shinichi Matsuda and Akihiro Fujikawa and Masahito Matsumoto and Eiji Watanabe and Hiroshi Kajiwara and Fumio Niimura and Masaharu Noda},
  journal={Neuron},
  year={2010},
  volume={66},
  pages={508-522}
}
Na(x) is the sodium-level sensor of body fluids in the brain involved in sodium homeostasis. Na(x)-knockout mice do not stop ingesting salt even when dehydrated. Here we report a case with clinical features of essential hypernatremia without demonstrable hypothalamic structural lesions, who was diagnosed as a paraneoplastic neurologic disorder. The patient had autoantibodies directed against Na(x), along with a ganglioneuroma composed of Schwann-like cells robustly expressing Na(x). The removal… CONTINUE READING
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