Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis?

  title={Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis?},
  author={Cees G. M. Kallenberg and J. W. Cohen Tervaert and Fokko Johannes van der Woude and Roel Goldschmeding and Albert E G K R von dem Borne and Jan J. Weening},
  journal={Immunology today},
  volume={12 2},
The demonstration of autoantibodies to neutrophil cytoplasmic antigens (ANCA) in (1) systemic vasculitides such as Wegener's granulomatosis, classic polyarteritis nodosa and the Churg Strauss syndrome and (2) idiopathic crescentic glomerulonephritis has placed these disorders within the spectrum of autoimmune diseases. The target antigens have been identified as myeloid lysosomal enzymes that are involved in tissue destruction by neutrophils. Recent data suggest a pathogenetic role for these… CONTINUE READING