Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

@article{Storch1998AutoimmunityTM,
  title={Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology},
  author={M. Storch and A. Stefferl and U. Brehm and Robert Weissert and E. Wallström and M. Kerschensteiner and T. Olsson and C. Linington and H. Lassmann},
  journal={Brain Pathology},
  year={1998},
  volume={8}
}
Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin. Many attempts have been undertaken previously to create animal models of chronic inflammatory demyelinating diseases through autoimmunity or virus infection. Recently, however, a new model of myelin oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis became available, which, in a very standardized and predictable way, leads to chronic (relapsing or… Expand
The role of myelin oligodendrocyte glycoprotein in autoimmune demyelination: a target for multiple sclerosis therapy?
Pathology of demyelinating diseases.
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